In Western blots, less than 5% cross-reactivity with recombinant human Neurolysin is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
A steady-state level of amyloid beta-peptide (Abeta) represents a balance between its biosynthesis from the amyloid precursor protein (APP) through the action of the beta and gamma-secretases and its catabolism by a variety of proteolytic enzymes. Thimet Oligopeptidase (THOP1) has been shown to promote A-beta degradation. It has also been shown to play a role in antigen presentation, metabolism of neuropeptides under 20 amino acids, and cytoplasmic peptide degradation.
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Protein Aliases: EC 3.4.24; EC 22.214.171.124; Endopeptidase 24.15; MP78; Thimet oligopeptidase
Gene Aliases: EP24.15; MEPD_HUMAN; MP78; THOP1; TOP
UniProt ID: (Human) P52888
Entrez Gene ID: (Human) 7064
Molecular Function: metalloprotease