Predicted to react with zebrafish, monkey and mouse based on sequence homology.
Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AIDA; Axin interaction partner and dorsalization antagonist; Axin interactor; Axin interactor, dorsalization-associated protein; C1orf80; dorsalization-associated protein
Gene Aliases: AIDA; C1orf80
UniProt ID: (Human) Q96BJ3
Entrez Gene ID: (Human) 64853