The antibody detects endogenous levels of total PHLDA2 protein.
TSSC3 (Tumor-suppressing STF cDNA 3 protein), also known as PHLDA2 (pleckstrin homology-like domain family A member 2), BWR1C, HLDA2 or IPL, is a cytoplasmic protein that is involved in fetal and placental growth. Expressed at high levels in placenta and adult prostate and at low levels in liver, lung and brain, TSSC3 is an apoptosis-related protein that acts as a negative growth regulator and is expressed during normal human development. TSSC3, a protein expressed from the maternal allele, is imprinted on placenta, liver and fetal tissues during embryogenesis and is removed once development is complete. Defects or alterations in the gene encoding TSSC3 are associated with several afflictions such as lung, ovarian and breast cancer, rhabdomyosarcoma, Beckwith-Wiedemann syndrome, Wilms tumor, low birth weight and adrenocortical carcinoma.
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Protein Aliases: Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; BRW 1C; BWR 1C; HLDA 2; Imprinted in placenta and liver protein; p17-Beckwith-Wiedemann region 1 C; p17-Beckwith-Wiedemann region 1C; p17-BWR1C; Pleckstrin homology-like domain family A member 2; pleckstrin homology-like domain, family A, member 2; Pphlda2; TSSC 3; tumor suppressing subchromosomal transferable fragment cDNA 3; tumor suppressing subtransferable candidate 3; Tumor-suppressing STF cDNA 3 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein; tumor-supressing STF cDNA 3
Gene Aliases: BRW1C; BWR1C; HLDA2; IPL; PHLDA2; TSSC3
UniProt ID: (Human) Q53GA4
Entrez Gene ID: (Human) 7262