The antibody detects endogenous levels of total AROS protein.
AROS, a nucleolar protein with an unknown function, interacts with extra ribosomal protein RPS19, playing a role in the signaling pathways that regulate rRNA transcription. The deduced amino acid sequence of AROS, derived from cDNA, defines an isoelectric point of 11.3. No known functional motifs were found in AROS except a short polylysine tract embedded in a putative nucleolar localization signal. At a basal level the protein is expressed ubiquitously with a significantly high level of expression in some tissues. Human AROS gene is mapped to chromosome 22q13.1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 40S ribosomal protein S19-binding protein 1; Active regulator of SIRT1; dJ1104E15.4; homolog of mouse S19 binding protein; RP5-1104E15.4; RPS19-binding protein 1; S19 binding protein
Gene Aliases: 2510038A11Rik; AI604923; AROS; RPS19BP1; S19BP