The antibody detects endogenous levels of total GPM6A protein.
Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene. Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
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Protein Aliases: GPM6; M6A; Neuronal membrane glycoprotein M6-a
Gene Aliases: GPM6; GPM6A; M6A
UniProt ID: (Human) P51674
Entrez Gene ID: (Human) 2823