The antibody detects endogenous levels of total Plectin-1 protein.
Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes. Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans. The expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development and it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms which carry out distinct and specific functions.
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Protein Aliases: HD1; Hemidesmosomal protein 1; PCN; Plectin; plectin 1, intermediate filament binding protein 500kDa; Plectin-1
Gene Aliases: EBS1; EBSMD; EBSND; EBSO; EBSOG; EBSPA; HD1; LGMD2Q; PCN; PLEC; PLEC1; PLEC1b; PLTN
UniProt ID: (Human) Q15149
Entrez Gene ID: (Human) 5339