Immunogen sequence: TGYKYEGVKF EKGNCGVSIM RSGEAMEQGL RDCCRSIRIG KILIQSDEET QRAKVYYAKF PPDIYRRKVL LMYPILSTGN TVIEAVKVLI EHGVQPSVII LLSLFSTPHG AKSIIQEFPE IT
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer.
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Protein Aliases: RP11-311P8.3; UMP pyrophosphorylase; UPRTase; uracil phosphoribosyltransferase (FUR1) homolog; Uracil phosphoribosyltransferase homolog
Gene Aliases: FUR1; UPP; UPRT
UniProt ID: (Human) Q96BW1
Entrez Gene ID: (Human) 139596