Immunogen sequence: DKTLPVFPKG NEVQIKVLNI GNNTMNISLP GEMVTLGPMS QTNAFMTFDV NKLTRINISS PGSPVTAVTD DFKQGQRHTL LVWAPNHYQV VKDGLNQKPE KGENGIRFVN TFNELITITM SGKVYANISS YNA
Highest antigen sequence identity to the following orthologs: Mouse - 74%, Rat - 72%.
In mammalian small intestine, the proton-coupled peptide transporter (PEPT) is responsible for the absorption of small peptides arising from digestion of dietary proteins. PEPT1, a hydrogen ion/peptide cotransporter, transports dipeptides and tripeptides, but not free amino acids or peptides with more than three amino acid residues. Its driving force for uphill transport requires proton binding and the presence of an inside-negative membrane potential. PEPT1 is 708 amino acid protein that contains 12 putative membrane-spanning domains. PEPT1 is expressed in Caco-2 cells. PEPT1 seems to play important roles in nutritional and pharmacological therapies. The mammalian kidney expresses a proton-coupled peptide transporter, PEPT2, that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate.
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Protein Aliases: Caco-2 oligopeptide transporter; Intestinal H(+)/peptide cotransporter; intestinal H+/peptide cotransporter; macrophage oligopeptide transporter PEPT1; Oligopeptide transporter, small intestine isoform; Peptide transporter 1; solute carrier family 15 (oligopeptide transporter), member 1; Solute carrier family 15 member 1
Gene Aliases: HPECT1; HPEPT1; PEPT1; SLC15A1
UniProt ID: (Human) P46059
Entrez Gene ID: (Human) 6564
Molecular Function: transporter