Immunogen sequence: LETNSCSEEE LSSPGRGGGG GGRLLLQPPG PELPPVPFPL QDLVPLGRLS RGEQQQQQQQ QPPPPPPPPG PLRPLAGPSR KGSFKIRLSR LFRTKSCNGG SGGGDGTGKR PSGELAASAA SLTDMGGSAG RELDAGRKPK LTR
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
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Protein Aliases: NAP-4; NAP4; Nck, Ash and phospholipase C binding protein; Nck, Ash and phospholipase C gamma-binding protein; NCK-associated protein 4; SOCS-7; SOCS7; Suppressor of cytokine signaling 7
Gene Aliases: NAP4; NCKAP4; SOCS6; SOCS7
UniProt ID: (Human) O14512
Entrez Gene ID: (Human) 30837