Immunogen sequence: MKQNKVPRKE LPHLKEEIPF ELSNLNQKLE EFRAKSREWD KQEILYQTHL ISLDAQQKLL SEKCNQFQKQ AQSYQTQLNG KKQCLEDSSS EIPRLICDPD PNCEINERDE FIIEKLKSAV NEIALSRNKL QD
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
CCDC67 (deuterosome assembly protein 1) is a key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. The protein interacts with CEP152 and recruits PLK4 to activate centriole biogenesis
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Protein Aliases: coiled-coil domain containing 67; Coiled-coil domain-containing protein 67; Deuterosome assembly protein 1
Gene Aliases: CCDC67; DEUP1
UniProt ID: (Human) Q05D60
Entrez Gene ID: (Human) 159989
Molecular Function: cytoskeletal protein