Immunogen sequence: GYKQEMTLIE TTAEAECTDI KILPYRSMEL KTVKPIDTSK TDPTVLLFVE SQYSQLGQDI IAILESSRFQ
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4; Glucosaminyl N-deacetylase/N-sulfotransferase 4; Heparan sulfate N-deacetylase 4; Heparan sulfate N-sulfotransferase 4; N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4; N-deacetylase/N-sulfotransferase 4; N-heparan sulfate sulfotransferase 4; N-HSST 4; NDST-4
Gene Aliases: HSST4; N-HSST; N-HSST 4; NDST-4; NDST4; NHSST4
UniProt ID: (Human) Q9H3R1
Entrez Gene ID: (Human) 64579