Immunogen sequence: PKPTLWAEPA SVIARGKPVT LWCQGPLETE EYRLDKEGLP WARKRQNPLE PGAKAKFHIP STVYDSAGRY RCYYETPAGW SEPSDPLELV ATG
Highest antigen sequence identity to the following orthologs: Mouse - 55%, Rat - 56%.
This gene is a member of the leukocyte immunoglobulin-likereceptor (LIR) family, which is found in a gene cluster atchromosomal region 19q13.4. The encoded protein belongs to thesubfamily B class of LIR receptors which contain two or fourextracellular immunoglobulin domains, a transmembrane domain, andtwo to four cytoplasmic immunoreceptor tyrosine-based inhibitorymotifs (ITIMs). Several other LIR subfamily B receptors areexpressed on immune cells where they bind to MHC class I moleculeson antigen-presenting cells and inhibit stimulation of an immuneresponse. Multiple transcript variants encoding different isoformshave been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD85 antigen-like family member C; CD85c; leucocyte Ig-like receptor B5; Leukocyte immunoglobulin-like receptor 8; Leukocyte immunoglobulin-like receptor subfamily B member 5; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5; LIR-8
Gene Aliases: CD85C; LILRB5; LIR-8; LIR8
UniProt ID: (Human) O75023
Entrez Gene ID: (Human) 10990