Immunogen sequence: LTEEEDSQTE LLIAEEKLSP EQEGQLMPRY EELAESVEEY VLDMLRDQLN RRQPIDNVSR NLLRLLTSTC GYKEVRLLAV QKLEMWLQNP K
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit and mediates 3-prime end processing of small nuclear RNAs U1 and U2. RNA polymerase II (Pol II) is an enzyme that is composed of twelve subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin.
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Protein Aliases: Int1; Integrator complex subunit 1
Gene Aliases: INT1; INTS1; KIAA1440; NET28; UNQ1821/PRO3434
UniProt ID: (Human) Q8N201
Entrez Gene ID: (Human) 26173