Immunogen sequence: QEKSRREEQE LWQEEEQKRR QERERKLREE HIRRQQKEEQ RHRQVGEIKS QEGKGHGRLL EPGTHQFASV PVRSSPLYEY\r
Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 63%.
This protein is an intermediate filament-associated protein that associates in regular arrays with keratin intermediate filaments (KIF) of the inner root sheath cells of the hair follicle and the granular layer of the epidermis. It later becomes cross-linked to KIF by isodipeptide bonds. It may serve as scaffold protein, together with involucrin, in the organization of the cell envelope or even anchor the cell envelope to the KIF network.