Immunogen sequence: ATRGEMMNTH RAIESNSQTS PLNAEVVQYA KEVVDFSSHY GSENSMSYTM WNLAGVPNVF PSSGDFTQTA VFRTYGTWWD QCPSA
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 93%.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 9 tandem leucine-rich repeats.
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Protein Aliases: F-box and leucine-rich repeat protein 4; F-box protein FBL4/FBL5; F-box/LRR-repeat protein 4
Gene Aliases: FBL4; FBL5; FBXL4; MTDPS13
UniProt ID: (Human) Q9UKA2
Entrez Gene ID: (Human) 26235