Immunogen sequence: YYINRRKRLV KLPCQTNIIT ILESYVKHFA INAAFSANER PRHHHVMPHA NMNVHYIPAE KNVDLCKEMV DGLRITFDYT LPLV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.
This gene encodes a nuclear protein and has similarity to drosophila male-specific lethal-3 gene. The drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus this encoded protein is thought to play a similar function in chromatin remodeling and transcriptional regulation. This gene has been found to undergo X inactivation. There are four alternatively spliced transcript variants of this gene encoding different isoforms.
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Protein Aliases: Male-specific lethal 3 homolog; Male-specific lethal-3 homolog 1; Male-specific lethal-3 protein-like 1; MSL3-like 1; MSL3L1
Gene Aliases: MSL3; MSL3L1
UniProt ID: (Human) A6NCU2
Entrez Gene ID: (Human) 10943