Immunogen sequence: KEQVANKGEP LALPLNVSEY CVPRGNRR
Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 62%.
This gene belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. This gene has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: BEX1; Brain-expressed X-linked protein 2; DJ79P11.1; hBex2; Protein BEX2; RP1-79P11.1
Gene Aliases: BEX1; BEX2; DJ79P11.1
UniProt ID: (Human) Q9BXY8
Entrez Gene ID: (Human) 84707