Immunogen sequence: GSGTSLEREQ FEGLGSTPDA KLDKTCISRA MKITTVNSVL PQNSVLGGVL KTKQQLKTLN HFDLTNGVLV ESLSEEPLPS LRRGRKRHCK TKHLEQ
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 74%.
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase RNF169; RING finger protein 169; RING-type E3 ubiquitin transferase RNF169
Gene Aliases: KIAA1991; RNF169
UniProt ID: (Human) Q8NCN4
Entrez Gene ID: (Human) 254225