Immunogen sequence: LNPEAAVLYE KDIQLFKSKV VDSVKVCTAR LFDQPKIEDP YAISFSPWNP SVHDEAREKM LTQKKPEEQH NKSVHVAGLS WVKPGSVQPF SKEEK
Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.
Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AKT-interacting protein; AKTIP; FT1; FTS; fused toes homolog; Fused toes protein; Fused toes protein homolog
Gene Aliases: AKTIP; AL023020; Fif; Ft; FT1; FTS