Immunogen sequence: MSEMAELSEL YEESSDLQMD VMPGEGDLPQ MEVGSGSREL SLRPSRSGAQ QLEEEGPMEE EEAQPMAAPE GKRSLANGPN AGEQPGQVAG ADFESED
Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 48%.
E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
Protein Aliases: 21 kDa pRb-associated protein; C15orf3; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1; CRI1; E1A-like inhibitor of differentiation 1; EID; EID-1; EID1; EP300-interacting inhibitor of differentiation 1; NB4 apoptosis related protein; Rb- and p300-binding protein EID-1; RBP21; retinoblastoma protein-associated protein
Gene Aliases: C15orf3; CRI1; EID-1; EID1; IRO45620; PNAS-22; PTD014; RBP21
UniProt ID: (Human) Q9Y6B2
Entrez Gene ID: (Human) 23741