Immunogen sequence: NFYYSAQKVE YSGGLGRQFF H\r
Highest antigen sequence identity to the following orthologs: Mouse - 52%, Rat - 52%.
TAS2R41 is a receptor that may play a role in the perception of bitterness and belongs to the G-protein receptor superfamily. TAS2R41 is expressed mainly in taste receptor cells of the tongue and the palate eptithelia. Structurally, the TAS2R41 gene encodes a seven trans-membrane receptor protein and is clustered together with eight other taste receptor genes on chromosome 7. The compound chloramphenicol is an agonist for the TAS2R41 protein. Further, TAS2R41 may play a role in sensing the chemical composition of the gastrointestinal content. The activity of TAS2R41 may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. TAS2R41 is expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells. Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli.
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Protein Aliases: MGC119928; MGC119929; T2R41; T2R59; Taste receptor type 2 member 41; Taste receptor type 2 member 59; taste receptor, type 2, member 41
Gene Aliases: T2R41; T2R59; TAS2R41
UniProt ID: (Human) P59536
Entrez Gene ID: (Human) 259287