Immunogen sequence: VLKYTAQNMEL QNKVQLLEEQ NLSLLDQLRK LQAMVIEISN KTS
Highest antigen sequence identity to the following orthologs - mouse 93%, rat 91%.
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element, an octameric palindrome. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. An additional transcript variant has been identified, but its biological validity has not been determined.
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Protein Aliases: basic leucine zipper protein; cAMP-responsive element-binding protein 3; CREB-3; cyclic AMP response element (CRE)-binding protein/activating transcription factor 1; Cyclic AMP-responsive element-binding protein 3; leucin zipper proitein; Leucine zipper protein; LUMAN; LZIP; N-terminal Luman; Processed cyclic AMP-responsive element-binding protein 3; small leucine zipper protein; Transcription factor LZIP-alpha
Gene Aliases: CREB3; LUMAN; LZIP; sLZIP
UniProt ID: (Human) O43889
Entrez Gene ID: (Human) 10488