Immunogen sequence: NSVKLNSLPSE YESGSACPAQ TVHYRPINLS SSENKIVNVS LADLRGGNRP NTGPLYTEAD RVIQRTNSMQ QLEQWIKIQK GRGHEEETRG VI\r
Highest antigen sequence identity to the following orthologs - mouse 81%, rat 82%.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
Protein Aliases: PEPP-2; PH domain-containing family A member 5; Phosphoinositol 3-phosphate-binding protein 2; phosphoinositol 3-phosphate-binding protein-2; pleckstrin homology domain containing, family A member 5; Pleckstrin homology domain-containing family A member 5
Gene Aliases: KIAA1686; PEPP-2; PEPP2; PLEKHA5
UniProt ID: (Human) Q9HAU0
Entrez Gene ID: (Human) 54477