Immunogen sequence: LGVQLPLAPAT SFPFWNLTGT NPASPDAGFP FVSRTGKTND FTKIKGWRGK FHSASASRNE GGNSESSLKN RSAFCSD
Highest antigen sequence identity to the following orthologs - mouse 94%, rat 95%.
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ12634; MAX dimerization protein 5; MAX gene-associated protein
Gene Aliases: KIAA0518; MAD5; MGA; MXD5
UniProt ID: (Human) Q8IWI9
Entrez Gene ID: (Human) 23269