Immunogen sequence: GLVRCFSTLQW LFRLDISFES QHILLRGDKT SRDMWATGSL PDFPAAAKFL GFRQRCIPRS LCLSECPLEP PSLTRLCATL KDCPGPLELQ LSCEFLSDQ
Highest antigen sequence identity to the following orthologs - mouse 55%, rat 50%.
NOD4 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD4 contains a CARD-like domain, a central NOD domain and a large LRR region. NOD4, an IFN-gamma-inducible nuclear protein, plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms. As a key negative regulator of NF-kappa-B and type I interferon signaling, NOD4 may be a useful target for manipulating immune responses against infectious or inflammation-associated diseases, including cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Caterpiller protein 16.1; CLR16.1; NLR family, CARD domain containing 5; NOD-like receptor C5; Nucleotide-binding oligomerization domain protein 27; Nucleotide-binding oligomerization domain protein 4; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5; nucleotide-binding oligomerization domains 27; Protein NLRC5
Gene Aliases: CLR16.1; NLRC5; NOD27; NOD4
UniProt ID: (Human) Q86WI3
Entrez Gene ID: (Human) 84166