Immunogen sequence: LEGQSTIEQDF EQVEMIRDSE SLNEMELAHS SFSEMQTAVS DMGLWRMQVF AMARLRFLKL
Highest antigen sequence identity to the following orthologs - mouse 61%, rat 59%.
The ATP-binding cassette (ABC) superfamily is comprised of transmembrane proteins involved in energy-dependent transport of a variety of substrates across membranes. ABCA6 is a 1,617 amino acid protein belonging to the ABC transporter family. ABCA6 is up-regulated during monocyte differentiation into macrophages, suggesting a role in macrophage lipid homeostasis. ABCA6 contains two ABC transporter domains and is expressed as three isoforms produced by alternative splicing. ABCA6 is present at highest levels in adult liver, with significant levels found in many adult tissues and fetal lung, kidney and liver.
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Protein Aliases: ABC transporter ABCA6; ATP-binding cassette A6; ATP-binding cassette sub-family A member 6; ATP-binding cassette, sub-family A (ABC1), member 6
Gene Aliases: ABCA6; EST155051
UniProt ID: (Human) Q8N139
Entrez Gene ID: (Human) 23460