Immunogen sequence: HRLMKHDLKVV ENVIAKSLLI KSNEGSYGFG LEDKNKVPII KLVEKGSNAE MAGMEVGKKI FAINGDLVFM RPFNEVDCFL KSCLNSRKPL RVLVSTKP
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.
Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DEP domain-containing protein 2; DEPDC2; P-Rex2; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein; protein phosphatase 1, regulatory subunit 129; PtdIns(3,4,5)-dependent Rac exchanger 2
Gene Aliases: DEP.2; DEPDC2; P-REX2; PPP1R129; PREX2
UniProt ID: (Human) Q70Z35
Entrez Gene ID: (Human) 80243