This target displays homology in the following species: Cow: 79%; Dog: 79%; Guinea Pig: 92%; Human: 100%; Mouse: 86%; Rat: 86%
Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation. May be involved in endoplasmic reticulum calcium ion homeostasis.
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Protein Aliases: BTB/POZ domain-containing protein KCTD17; potassium channel tetramerisation domain containing 17
Gene Aliases: 2900008M13Rik; AA414907; AW742389; BOS_5669; KCTD17; N28155; RGD1311154
UniProt ID: (Human) Q8N5Z5