This target displays homology in the following species: Cow: 93%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
PLEKHF2 may play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis.
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Protein Aliases: EAPF; Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains; PH and FYVE domain-containing protein 2; PH domain-containing family F member 2; phafin 2; Phafin-2; Phafin2; pleckstrin homology domain containing, family F (with FYVE domain) member 2; Pleckstrin homology domain-containing family F member 2; Zinc finger FYVE domain-containing protein 18
Gene Aliases: 1110070J07Rik; AA673237; BOS_14117; EAPF; PHAFIN2; PLEKHF2; ZFYVE18