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This target displays homology in the following species: Human: 100%
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cerebral protein 9; kinase non-catalytic C-lobe domain (KIND) containing 1; Kinase non-catalytic C-lobe domain-containing protein 1; kind; KIND domain-containing protein 1; Protein very KIND; Ras-GEF domain-containing family member 2; RasGEF domain family, member 2; v-KIND
Gene Aliases: bB439H18.3; C10orf23; hucep-9; KIAA1768; KNDC1; RASGEF2; VKIND
UniProt ID: (Human) Q76NI1
Entrez Gene ID: (Human) 85442
Molecular Function: G-protein modulator protein-binding activity modulator guanyl-nucleotide exchange factor
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