Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243).
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Protein Aliases: BTB/POZ domain-containing protein KCTD17; KCTD17
Gene Aliases: KCTD17
UniProt ID: (Human) Q8N5Z5
Entrez Gene ID: (Human) 79734