This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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Protein Aliases: Nedd4 WW binding protein 4; NEDD4 WW domain-binding protein 4; Prostate transmembrane protein androgen induced 1; Protein TMEPAI; Solid tumor-associated 1 protein; Transmembrane prostate androgen-induced protein; transmembrane, prostate androgen induced RNA
Gene Aliases: 2210418I02Rik; AW455466; Erg1.2; N4wbp4; PMEPA1; STAG1; TMEPAI
UniProt ID: (Human) Q969W9