This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human PML/RNF71/TRIM19.
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER). This protein was shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, as well as with ubiquitin protein ligase E6AP, and thus suggests that this protein may be involved in the ubiquitin mediated proteolytic pathway in cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: PML/RARA fusion; pml1; probable transcription factor PML; Promyelocytic leukemia protein; promyelocytic leukemia, inducer of; Protein PML; RING finger protein 71; tripartite motif protein TRIM19; Tripartite motif-containing protein 19
Gene Aliases: MYL; PML; PP8675; RNF71; TRIM19
UniProt ID: (Human) P29590
Entrez Gene ID: (Human) 5371