Immunogen sequence: PSKVGKRCRK TSDPRRSIVE CQPDASATPG VGTADSPAAP TDSRDDQKGL SLSPQSPPER RGYPGPGLRS DWHASSPLLI TSDTEHVTLL SEAEHH
Regulator of DNA replication and S/M and G2/M checkpoints. Regulates the triggering of DNA replication initiation via its interaction with TOPBP1 by participating in CDK2-mediated loading of CDC45L onto replication origins. Required for the transition from pre-replication complex (pre-RC) to pre-initiation complex (pre-IC). Required to prevent mitotic entry after treatment with ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: TOPBP1-interacting checkpoint and replication regulator; topBP1-interacting replication-stimulating protein; TopBP1-interacting, replication-stimulating protein; Treslin
Gene Aliases: C15orf42; SLD3; TICRR; Treslin
UniProt ID: (Human) Q7Z2Z1
Entrez Gene ID: (Human) 90381