This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants.
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Protein Aliases: IL-1 receptor-associated kinase M; Interleukin-1 receptor-associated kinase 3; IRAK-3; IRAK-M; IRAK3; IRAKM
Gene Aliases: ASRT5; IRAK3; IRAKM
UniProt ID: (Human) Q9Y616
Entrez Gene ID: (Human) 11213