Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: KSKSDRIVNE TLYENTKLLS ATGESEKQFQ EAIIVFQEEF KCCGLVNGAA DWGNNFQHYP ELCACLDKQR PCQSYNGKQV YKETCISFIK D; Positive Samples: Mouse lung, Rat lung; Cellular Location: Membrane, Multi-pass membrane protein
TSPAN8 (tetraspanin 8), also known as TM4SF3 or CO-029, is a 237 amino acid multi-pass membrane protein that belongs to the tetraspanin family of transmembrane proteins and is thought to play a role in signal transduction events that influence cell development, activation, growth and motility. Localized to the cell membrane, TSPAN8 is expressed in colon, gastric, renal and pancreatic cancers, strongly suggesting a role in cancer formation and metastasis. The gene encoding TSPAN8 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
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Protein Aliases: D6.1A; Tetraspanin-8; Tetraspanin8; transmembrane 4 superfamily member 3; Tspan-8
Gene Aliases: C76990; CO-29; E330007O21Rik; Tm4sf3; Tspan8
UniProt ID: (Mouse) Q8R3G9
Entrez Gene ID: (Rat) 171048, (Mouse) 216350
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