Immunogen sequence: MVSTPENRQT FITSVIKFLR QYEFDGLDFD WEYPGSRGSP PQDKHLFTVL VQEMREAFEQ EAKQINKPRL MVTAAVAAGI SNIQSGYEIP QLSQYLDYIH VMTYDLHGSW EGYTGENSPL YKYPTDTGSN AYLNVDYVMN YWKDNGAPAE KLIVGFPTYG HNFILSNPSN TGIGAPTSGA GPAGPYAKES GIWAYYEICT FLKNGATQGW DAPQEVPYAY QGNVWVGYDN IKSFDIKAQW LKHNKFGGAM VWAIDLDDFT GTFCNQGKFP LISTLKKALG LQSASCTAPA QPIEPITAAP SGSGNGSGSS SSGGSSGGSG FCAVRANGLY PVANNRNAFW HCVNGVTYQQ NCQAGLVFDT SCDCCNWA; Positive Samples: U-87MG, HepG2, Mouse stomach, Rat lung, Rat stomach; Cellular Location: Cytoplasm
CHIA degrades chitin and chitotriose. May participate in the defense against nematodes and other pathogens. There are 3 named isoforms produced by alternative splicing. CHIA is induced via a T helper-2 (Th2)-specific, interleukin-13-mediated pathway in epithelial cells and macrophages. CHIA may be an important mediator of IL13-induced responses in Th2-dominated disorders such as asthma. CHIA hydrolysis N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins.
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Protein Aliases: acidic chitinase; Acidic mammalian chitinase; AMCase; eosinophil chemotactic cytokine; Lung-specific protein TSA1902; small acid mammalian chitinase; YNL
Gene Aliases: 2200003E03Rik; AMCASE; CHIA; Chia1; CHIT2; TSA1902; YNL