Immunogen sequence: FSGAVTRGRK VQKEGKISYA DFVWFLISEE DKKTPTSIEY WFRCMDLDGD GALSMFELEY FYEEQCRRLD SMAIEALPFQ DCLCQMLDLV KPRTEGKITL QDLKRCKLAN VFFDTFFNIE KYLDHEQKEQ ISLLRDGDSG GPELSDWEKY AAEEYDILVA EETAGEPWED GFEAELSPVE QKLSALRSPL AQRPFFEAPS PLGAVDLYEY ACGDEDLEPL; Positive Samples: HeLa, SW620, BT-474, SKOV3, mouse skeletal muscle; Cellular Location: Nucleus
Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein Aliases: NY-REN-8; NY-REN-8 antigen; PP2A subunit B isoform PR48; PP2A, subunit B, PR48 isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B'', beta; protein phosphatase 2 regulatory subunit B'', beta; protein phosphatase 2, regulatory subunit B'', beta; Protein phosphatase 2A 48 kDa regulatory subunit; serine/threonine protein phosphatase 2A, 48kDa regulatory subunit B; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
Gene Aliases: NYREN8; PPP2R3B; PPP2R3L; PPP2R3LY; PR48
UniProt ID: (Human) Q9Y5P8
Entrez Gene ID: (Human) 28227