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Recommended positive controls: HeLa, HeLa nucleus.
Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (88%), Xenopus laevis (86%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
An increased intracellular Ca2+ concentration induces apoptotic cell death. Transiently elevated Ca2+ concentrations are required for glucocorticoid-mediated and T cell receptor-mediated pathways, leading to T cell apoptosis. ALG-2 (for apoptosis-linked gene 2) is a Ca2+ -binding protein that participates in regulatory events occuring late in the apoptotic program and where several death signals converge. ALG-2 is a protein expressed in normal brain, and to a greater extent in ischemic brain. The ALG-2 protein contains five EF-hand-like motifs and shares homology with members of the penta EF-hand family, which includes Calpain small subunits sorcin and Grancalcin.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALG-2; apoptosis-linked gene 2 protein; Apoptosis-linked gene 2 protein homolog; probable calcium-binding protein ALG-2; Programmed cell death protein 6
Gene Aliases: ALG-2; ALG2; PDCD6; PEF1B
UniProt ID: (Human) O75340
Entrez Gene ID: (Human) 10016
Molecular Function: actin or actin-binding cytoskeletal protein
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