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A suggested positive control is EL4 cell lysate.
PA5-34446 can be used with blocking peptide PEP-1488.
Dyneins are multi-subunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein is an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. It performs functions necessary for cell survival such as organelle transport and centrosome assembly. TCTEX1 is a cytoplasmic dynein light chain found in a complex with Na+ CP type X (SCN10A). TCTEX1D3, also called TCTE3, has been identified as a gene responsible for congenital diaphragmatic hernia (CDH).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dynein light chain Tctex-type protein 2; LC2; t-complex testis-expressed 4; T-complex testis-specific protein 2; T-complex testis-specific protein 3; T-complex-associated testis-expressed protein 3; T-complex-associated testis-expressed protein 4; Tcte-3; TCTEX-2; TCTEX-4; Tctex1 domain containing 3; Tctex1 domain-containing protein 3
Gene Aliases: D17Leh117c; DYNLT2; LC2; Tcte-3; TCTE3; Tctex-2; Tctex-4; TCTEX1D3; Tctex2; Tctex4
UniProt ID: (Human) Q8IZS6, (Mouse) P11985
Entrez Gene ID: (Human) 6991, (Mouse) 21647, (Rat) 365153
Molecular Function: microtubule or microtubule-binding cytoskeletal protein
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