Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Recommended positive controls: A431, H1299.
Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; hAxin; LA16c-314G4.3; MGC52315; protein phosphatase 1, regulatory subunit 49
Gene Aliases: AXIN; AXIN1
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