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Peptide sequence: GGPYGESEAP APPGPGTRWP YRSRDTRRSF PEPEEPPEGG SYAGSLAEPY
Sequence homology: Cow: 93%; Dog: 86%; Horse: 86%; Human: 100%; Rabbit: 79%
The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: latent transforming growth factor-beta binding protein 4L; Latent-transforming growth factor beta-binding protein 4; LTBP-4
Gene Aliases: ARCL1C; LTBP-4; LTBP4; LTBP4L; LTBP4S
UniProt ID: (Human) Q8N2S1
Entrez Gene ID: (Human) 8425
Molecular Function: extracellular matrix structural protein
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