Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: RGFRIQFQKK SEKEKTNKET ETESGNENSG YNSDEQKTTD TASLPPKSCE SSDPEQRNSS CGPPHQRADQ RPPRPASHPQ ASFNLASPEK VSNTT
Highest antigen sequence identity to the following orthologs: Mouse - 49%, Rat - 45%.
Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia-spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells-Sertoli cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IgSF5; immunoglobulin superfamily 5 like; Immunoglobulin superfamily member 5; immunoglobulin superfamily, member 5; JAM-4; Junctional adhesion molecule 4
Gene Aliases: GSF5; IGSF5; JAM4
UniProt ID: (Human) Q9NSI5
Entrez Gene ID: (Human) 150084
Molecular Function: defense/immunity protein immunoglobulin
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