Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Positive Control: SK-N-SH, IMR32, human MMP24-transfected 293T, mouse brain
Predicted Reactivity: Rat (83%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins, termed matrix metalloproteinases (MMPs), are involved in the modulation of cell-matrix interactions. MMPs are Zn (2+)-binding endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: matrix metallo protease; matrix metallopeptidase 24 (membrane-inserted); matrix metalloproteinase 24; matrix metalloproteinase 24 (membrane-inserted); Matrix metalloproteinase-21; Matrix metalloproteinase-24; membrane type 5-MMP; membrane-type 5 matrix metalloproteinase; Membrane-type matrix metalloproteinase 5; Membrane-type-5 matrix metalloproteinase; MMP; MMP-21; MMP-24; MMPs; MT-MMP 5; MT5-MMP; Processed matrix metalloproteinase-24; RP4-614O4.10
Gene Aliases: AU040325; MMP-24; Mmp21; MMP24; MMP25; MT-MMP 5; MT-MMP5; MT5-MMP; MT5MMP; MTMMP5
UniProt ID: (Human) Q9Y5R2, (Mouse) Q9R0S2
Entrez Gene ID: (Human) 10893, (Mouse) 17391
Molecular Function: metalloprotease
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