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Immunogen sequence: ESLKSRVQSY FDGIKADWLD SIRPQKEGDF RKEINKWWNN LSDGQR
This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mitochondrial intramembrane cleaving protease PARL; mitochondrial intramembrane-cleaving protease PARL; P-beta; Pbeta; Presenilins-associated rhomboid-like protein, mitochondrial; rhomboid 7 homolog 1
Gene Aliases: PARL; PRO2207; PSARL; PSARL1; PSENIP2; RHBDS1
UniProt ID: (Human) Q9H300
Entrez Gene ID: (Human) 55486
Molecular Function: serine protease
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