|Tested species reactivity||Human, Mouse, Non-human primate, Rat, Xenopus|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 400-450 of human PACSIN 2.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.2% gelatin|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Western Blot (WB)||0.02-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with mouse, rat, canine, bovine, and chicken based on sequence homology.
PACSIN 2, a 486 AA phosphoprotein is a novel member of the PACSIN family of cytoplasmic adapter proteins. It is an isoform of PACSIN with a CDC15 N-terminal domain, a C-terminal SH3 domain, 3 conserved regions specific to the PACSIN family, and 3 asn-pro-phe (NPF) motifs, which potentially bind to EH domains. This protein is known to display a ubiquitous expression pattern with the highest levels of expression in brain. Reports suggest that PACSIN 2 participates in the organization of the actin cytoskeleton, the regulation of vesicular traffic. It also participates in endocytic internalization and endocytic receptor recycling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.