PAD4 is a member of a family of enzymes responsible for the conversion of arginine residues to citrulline residues via catalyzation of the deimination of the arginine residues. PAD4 down-regulates histone H3 and H4 arginine methylation, both by preventing arginine methylation by CARM1 and HRMT1L2/PRMT1 and by converting methylarginine to citrulline. This protein may play a role in granulocyte and macrophage development leading to inflammation and immune response.
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Protein Aliases: HL-60 PAD; PAD4; PADI-H protein; PADI4; PADI5; PDI4; PDI5; peptidyl arginine deiminase, type IV; peptidyl arginine deiminase, type V; Peptidylarginine deiminase IV; protein-arginine deiminase; Protein-arginine deiminase type IV; Protein-arginine deiminase type-4
Gene Aliases: PAD; PAD4; PADI4; PADI5; PDI4; PDI5
UniProt ID: (Human) Q9UM07
Entrez Gene ID: (Human) 23569
Molecular Function: hydrolase