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      View (16) other PAI1 antibodies

      Invitrogen

      PAI1 Monoclonal Antibody (1D5)

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      Catalog # MA5-17171

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      Product Details

      TESTED APPLICATIONS DILUTION
      Flow Cytometry (Flow) 1:200 - 1:400
      Immunohistochemistry (IHC) 1:200 - 1:1000
      Western Blot (WB) 1:500 - 1:2000
      PUBLISHED APPLICATIONS
      Western Blot (WB) See 1 publications below
      Species reactivity Human, Mouse
      Published species Human
      Host / Isotype Mouse / IgG1
      Class Monoclonal
      Type Antibody
      Clone 1D5
      Immunogen Purified recombinant fragment of human SERPINE1 expressed in E. Coli.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification purified
      Storage buffer PBS with 0.5% proprietary stabilizer
      Contains 0.05% sodium azide
      Storage conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
      RRID AB_2538642

      Product Specific Information

      MA5-17171 targets SERPINE1 in FACS, IHC, pep-ELISA, and WB applications and shows reactivity with Human samples.

      The MA5-17171 immunogen is purified recombinant fragment of human SERPINE1 expressed in E. Coli.

      MA5-17171 detects SERPINE1 which has a predicted molecular weight of approximately 45kDa.

      Background/Target Information

      This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References (1)

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      Bioinformatics

      Protein Aliases: Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; Plasminogen activator inhibitor 1; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

      Gene Aliases: PAI; PAI-1; PAI1; PLANH1; SERPINE1

      UniProt ID: (Human) P05121

      Entrez Gene ID: (Human) 5054, (Mouse) 18787

      Molecular Function: enzyme modulator protease inhibitor serine protease inhibitor

      Function(s) Blue Arrow Icon
      chronological cell aging angiogenesis platelet degranulation circadian rhythm regulation of receptor activity negative regulation of plasminogen activation negative regulation of endopeptidase activity negative regulation of smooth muscle cell migration positive regulation of blood coagulation negative regulation of blood coagulation extracellular matrix organization negative regulation of cell migration positive regulation of interleukin-8 production negative regulation of cell adhesion mediated by integrin positive regulation of leukotriene production involved in inflammatory response fibrinolysis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter positive regulation of receptor-mediated endocytosis positive regulation of inflammatory response defense response to Gram-negative bacterium negative regulation of fibrinolysis negative regulation of vascular wound healing negative regulation of wound healing cellular response to lipopolysaccharide positive regulation of monocyte chemotaxis negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of smooth muscle cell-matrix adhesion negative regulation of endothelial cell apoptotic process female gonad development negative regulation of peptidase activity positive regulation of gene expression negative regulation of gene expression cellular response to drug wound healing regulation of cell proliferation regulation of angiogenesis positive regulation of fibroblast proliferation positive regulation of coagulation positive regulation of keratinocyte migration cellular response to interleukin-1 cellular response to transforming growth factor beta stimulus positive regulation of calcium ion import
      Process(es) Blue Arrow Icon
      protease binding
       serine-type endopeptidase inhibitor activity
       receptor binding
       protein binding
       peptidase inhibitor activity

      Suggested Secondary Antibodies

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