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      PAI1 Monoclonal Antibody (1D5)

      See 18 other PAI1 antibodies ›
      PAI1 Monoclonal Antibody for Western Blot, IHC and Flow

      Catalog#: MA5-17171 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      MA5-17171 100 ug
      309.00
      Please enter a quantity in the range of 1 to 199.
      Suggested Secondary Antibodies

      Anti-Mouse Secondary Antibodies (597)
      Alexa Fluor® Anti-Mouse Secondary Antibodies (122)
      HRP Anti-Mouse Secondary Antibodies (86)

      Product Details

      References

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human, Mouse
      Published species reactivity Human
      Host / Isotype Mouse / IgG1
      Class Monoclonal
      Type Antibody
      Clone 1D5
      Immunogen Purified recombinant fragment of human SERPINE1 expressed in E. Coli.
      Conjugate Unconjugated
      Form Liquid
      Concentration 1 mg/ml
      Purification purified
      Storage buffer PBS with 0.5% proprietary stabilizer
      Contains 0.05% sodium azide
      Storage Conditions Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
      Tested Applications Dilution *
      Flow Cytometry (Flow) 1:200 - 1:400
      Immunohistochemistry (IHC) 1:200 - 1:1000
      Western Blot (WB) 1:500 - 1:2000

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Published Applications
      Western Blot (WB) See 1 publications below

      Product Specific Information

      MA5-17171 targets SERPINE1 in FACS, IHC, pep-ELISA, and WB applications and shows reactivity with Human samples.

      The MA5-17171 immunogen is purified recombinant fragment of human SERPINE1 expressed in E. Coli.

      MA5-17171 detects SERPINE1 which has a predicted molecular weight of approximately 45kDa.

      Background/Target Information

      This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      References

      Western Blot

      Species Dilution Title Authors Journal (Vol:Pg) Year
      Human 1:600 Association of autotaxin and lysophosphatidic acid receptor 3 with aggressiveness of human breast carcinoma.
      MA5-17171 was used in western blot to evaluate the LPA-producing enzyme autotaxin and LPAR3 as potential therapeutic targets in breast cancer patients       		Popnikolov NK,Dalwadi BH,Thomas JD,Johannes GJ,Imagawa WT Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (33:2237) 2012

      Bioinformatics

      Protein Aliases:

      Endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; PAI; Plasminogen activator inhibitor 1; plasminogen activator inhibitor, type I; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI); serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

      Gene Aliases:

      PAI; PAI-1; PAI1; PLANH1; SERPINE1

      UniProt ID:

      (Human) P05121

      Entrez Gene ID:

      (Human) 5054, (Mouse) 18787

      Molecular Function:

      enzyme modulator protease inhibitor serine protease inhibitor

      Function(s) Process(es)

      Documents

      Material safety data sheets (MSDS)

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