MA5-15527 targets PAK2 in IF, IHC, and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15527 immunogen is purified recombinant fragment of PAK2 expressed in E. Coli.
MA5-15527 detects PAK2 which has a predicted molecular weight of approximately 61kDa.
The p21 activated kinases are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
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Protein Aliases: C-t-PAK2; Gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p27; p34; p58; PAK-2; PAK-2p27; PAK-2p34; PAK2; PAK65; PAKgamma; S6/H4 kinase; Serine/threonine-protein kinase PAK 2
Gene Aliases: PAK2; PAK65; PAKgamma
UniProt ID: (Human) Q13177
Entrez Gene ID: (Human) 5062