MA5-15408 targets PAR4 in IHC and WB applications and shows reactivity with Human samples.
The MA5-15408 immunogen is purified recombinant fragment of PAR4(aa1-330) expressed in E. Coli.
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
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Protein Aliases: Par-4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4; Prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor PAR4; WT1-interacting protein
Gene Aliases: Par-4; PAR4; PAWR
UniProt ID: (Human) Q96IZ0
Entrez Gene ID: (Human) 5074